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September 18, 2025Archivio Italiano di Urologia e AndrologiaOpen Access

Prognostic value of combined tumor regression grade and TNM stage in muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy

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Authors

MLManuel LopesHospitais da Universidade de CoimbraJPJosé PereiraMTMaría José Temido

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Implication

Retrospective analysis indicates tumor regression grade enhances survival predictions in muscle-invasive bladder cancer, suggesting improved patient outcomes.

Key Points

  • Complete response observed in 43.1% of patients, with significantly improved survival rates.
  • Median overall survival was 19 months; 3- and 5-year survival rates were 28.6% and 14.3%, respectively.
  • Absence of nodal involvement and complete response were independent predictors of better overall survival.
  • Integration of tumor regression grade with TNM staging enhances prognostic stratification for treatment planning.

Cite This Study

Lopes et al. (2025) studied this question.

synapsesocial.com/papers/68d434d6713b0b5dfea73db1https://doi.org/10.4081/aiua.2025.14264
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