September 18, 2025Endocrinology Diabetes & MetabolismOpen Access

Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches

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Authors

BHBoštjan HostnikUniversity of Ljubljana GTGašper ToninLjubljana University Medical Centre AJAndrej JanežUniversity of Ljubljana

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Implication

This narrative review highlights the pathophysiology and genetic associations of erectile dysfunction in diabetes mellitus, suggesting tailored therapeutic approaches.

Key Points

Erectile dysfunction prevalence is over 3.5 times higher in men with diabetes compared to those without, affecting psychosocial well-being.
Diabetic erectile dysfunction involves complex interactions among systemic changes, including endothelial dysfunction and hormonal imbalances.
Genetic studies reveal associations between erectile dysfunction severity and polymorphisms in candidate genes affecting nitric oxide availability.
Emerging treatments like gene therapy and stem cell therapy show promise but require further research for validation in clinical settings.

Cite This Study

Hostnik et al. (2025) studied this question.

synapsesocial.com/papers/68d433b8713b0b5dfea737e4 https://doi.org/10.1002/edm2.70099

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Implication

This narrative review highlights the pathophysiology and genetic associations of erectile dysfunction in diabetes mellitus, suggesting tailored therapeutic approaches.

Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

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