September 18, 2025BiomoleculesOpen Access

Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment

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This review discusses PKM2's role in metabolism and epigenetics, suggesting it as a new target for liver disease treatment.

Targeting pyruvate kinase M2 may improve treatment options for liver diseases, highlighting its pivotal role.
Post-translational modifications affect PKM2's activity and localization, influencing its regulatory role.
Understanding PKM2's integrative functions in epigenetics and metabolism aids in therapeutic development.
Potential PKM2 regulators offer new avenues for addressing aberrant glycolysis in liver diseases.

Zhang et al. (2025) studied this question.

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