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September 18, 2025MEDISAINSOpen Access

In vivo study of Centella asiatica leaf extract cream for Matrix Metalloproteinase-1 inhibition and collagen enhancement to prevent photoaging

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Authors

SPSri PurmawantiJWJ. W.TSTitiek Sumarawati

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Overview

Experimental study shows Centella asiatica cream affects collagen levels and MMP-1 in skin, suggesting potential for photoaging mitigation.

Key Points

  • The application of Centella asiatica cream reduced MMP-1 expression and improved collagen density in skin tissue exposed to UVB.
  • MMP-1 expression was highest in the negative control group and significantly decreased in groups treated with Centella asiatica cream.
  • Collagen density analysis revealed significant differences, with higher levels observed in groups treated with 10% and 20% Centella asiatica cream.
  • Study results suggest that topical application of Centella asiatica may help prevent skin aging due to UVB exposure.

Cite This Study

Purmawanti et al. (2025) studied this question.

synapsesocial.com/papers/68d433b0713b0b5dfea73630https://doi.org/10.30595/medisains.v0i0.24719
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