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September 18, 2025Journal of Viral Hepatitis

Longitudinal Profiles of Cytokines and Chemokines in Self‐Limiting Hepatitis E

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Authors

PBPooja BhatiaAMAas MohdHKHarshita Katiyar

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Overview

Longitudinal analysis reveals distinct immune responses during hepatitis E infection, highlighting cytokines and chemokines.

Key Points

  • Distinct immune signatures were observed in patients with self-limiting hepatitis E, especially cytokine responses.
  • The median time until HEV RNA became undetectable was 13 days after symptom onset, reflecting robust immune activity.
  • Cytokines such as IFN-γ peaked significantly before HEV RNA clearance, indicating a crucial role in immune response.
  • Significantly elevated chemokines CCL3, CXCL6, CXCL9, and CXCL10 were found in AVH-E patients compared to healthy controls.

Cite This Study

Bhatia et al. (2025) studied this question.

synapsesocial.com/papers/68d433b0713b0b5dfea73389https://doi.org/10.1111/jvh.70088
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  5. 5Clinical Characteristics and Epidemiological Features of Hepatitis E Virus Infection Among People Living with HIV in Shanghai, China2025