September 18, 2025MedicinaOpen Access

Improving MDS Risk Assessment: The Role of Monocytopenia and Lymphocytopenia Beyond IPSS-R

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Discussion

Retrospective analysis shows monocytopenia and lymphocytopenia impact overall survival in MDS, suggesting important prognostic roles.

Patients with monocytopenia had a median overall survival of 20 months compared to 60 months without this risk factor.
Lymphocytopenia showed a significant survival impact, with median overall survival of 17 months versus 29 months when present.
Both monocytopenia and lymphocytopenia were identified as independent prognostic factors alongside IPSS-R, informing risk assessments.
The study underscores the importance of including host immunity parameters for improved prognostic insights in MDS.

Virijević et al. (2025) studied this question.

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