Narrative review explores gut-brain axis involvement in autism spectrum disorder, suggesting therapeutic improvements through microbiome interventions.
Key Points
The microbiota-gut-brain axis involves multiple pathways that influence brain development and function, showing therapeutic potential for autism spectrum disorder (ASD).
Individuals with ASD typically display gut dysbiosis, characterized by reduced microbial diversity and an increase in potentially harmful bacteria.
Narrative review methodology synthesized findings from human, animal, and in vitro studies detailing dysbiosis and its impact on neurodevelopment and behavior.
Interventions targeting the gut ecosystem, like probiotics and dietary changes, offer promise, but further large-scale studies are needed to validate these therapeutic approaches.