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September 18, 2025International Journal of Gynecological Pathology

HPV-associated Endocervical Adenocarcinoma In Situ (AIS) With an ER+/Vimentin+/CEA− immunophenotype Mimicking Tubo-endometrioid Metaplasia

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Authors

JXJin XuQLQinyuan LiPWPaul Weisman

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Overview

Case report reveals immunophenotype ER+/Vimentin+/CEA− in AIS, suggesting misdiagnosis potential with TEM.

Key Points

  • AIS cases displayed an immunophenotype similar to tubo-endometrioid metaplasia, potentially leading to misdiagnosis.
  • Both diagnosed AIS cases were positive for high-risk HPV, confirming their association with the virus.
  • The morphology and immunophenotype of diagnosed AIS mimicked TEM, despite lacking true cilia in the observed cells.
  • Extensive p16 expression in these cases emphasizes that similar immunophenotypes do not guarantee benignity.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d433a3713b0b5dfea72df2https://doi.org/10.1097/pgp.0000000000001129
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