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September 18, 2025Molecular PsychiatryOpen Access

Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons

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Authors

XSXiao SuHZHanwen ZhangHYHong Yan

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Overview

Study explores SETD1A mutations' effect on synaptic function in human neurons, suggesting links to schizophrenia.

Key Points

  • Dysregulation in synaptic function was observed due to SETD1A mutations in human neurons.
  • Five isogenic pairs of human induced pluripotent stem cells were engineered to study these mutations.
  • The mutations resulted in significantly altered neuronal morphology and synaptic plasticity.
  • Identifying the alterations provides insights into the potential pathophysiology of schizophrenia.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/68d4339c713b0b5dfea72ad1https://doi.org/10.1038/s41380-025-03246-z
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