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September 17, 2025

Pre-infusion risk factors predict severe infectious complications of CAR T-cell therapy in pediatric and adult patients with B-ALL.

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Authors

ACAugust A. CulbertFGFlavia GavaYVYannis K. Valtis

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Overview

Retrospective analysis identifies pre-infusion factors predicting severe infections in patients with B-ALL, suggesting targeted prevention strategies.

Key Points

  • Older age and prior severe infection are significant risk factors for severe infections in patients receiving CAR T-cells.
  • Among 350 patients, 79 (23%) developed severe infections post-infusion, with bloodstream infections being the most common.
  • The ALL-HT score serves as a critical tool for evaluating infection risk, emphasizing the role of baseline thrombocytopenia.
  • High-risk patients classified by ALL-HT faced significantly increased rates of severe infections, guiding preventive measures.

Cite This Study

Culbert et al. (2025) studied this question.

synapsesocial.com/papers/68d4328c713b0b5dfea71f49https://doi.org/10.1136/jitc-2025-012436
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