September 17, 2025

Blood Biomarkers of Fibrosis as Alternatives to FibroScan

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Cross-sectional analysis compares noninvasive methods for diagnosing liver fibrosis in MAFLD, indicating potential alternatives.

FIB-4 score achieved the highest specificity (78%) and sensitivity (85%) among alternative methods compared to FibroScan®.
The area under the curve for FIB-4 was 0.82, closely aligning with the 0.88 of FibroScan®, suggesting it as a viable alternative.
FIB-5 and APRI showed moderate effectiveness with sensitivities of 80% and 76%, respectively, but lower specificity.
The AST/ALT ratio had poor diagnostic capability with 60% specificity and 65% sensitivity, making it less reliable.

Gupta et al. (2025) studied this question.

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September 17, 2025

View Full Paper

Ask AI

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Authors

Cross-sectional analysis compares noninvasive methods for diagnosing liver fibrosis in MAFLD, indicating potential alternatives.

FIB-4 score achieved the highest specificity (78%) and sensitivity (85%) among alternative methods compared to FibroScan®.
The area under the curve for FIB-4 was 0.82, closely aligning with the 0.88 of FibroScan®, suggesting it as a viable alternative.
FIB-5 and APRI showed moderate effectiveness with sensitivities of 80% and 76%, respectively, but lower specificity.
The AST/ALT ratio had poor diagnostic capability with 60% specificity and 65% sensitivity, making it less reliable.

Gupta et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark