September 17, 2025Journal of Heterocyclic Chemistry

p‐TSA Catalyzed One‐Pot Synthesis of Novel Chromen and Benzo[h]quinoline‐Based Trisubstituted Methanes

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Synthesis of novel trisubstituted methanes achieved with yields of 84%–92%, showcasing the efficiency of the method.
The use of p-toluene sulfonic acid as a catalyst eliminates the need for column chromatography and supports various functional groups.
Structured analysis confirmed the identities of new compounds, indicating their potential in drug design.
The method is cost-effective, non-toxic, and offers short reaction times while generating valuable products.

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Implication

This research demonstrates the effective use of p-toluene sulfonic acid as a catalyst for synthesizing trisubstituted methanes, highlighting its eco-friendly properties.

Cite This Study

Dastjerdi et al. (2025) studied this question.

synapsesocial.com/papers/68d4328c713b0b5dfea71d8a https://doi.org/10.1002/jhet.70069

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Implication

This research demonstrates the effective use of p-toluene sulfonic acid as a catalyst for synthesizing trisubstituted methanes, highlighting its eco-friendly properties.

p‐TSA Catalyzed One‐Pot Synthesis of Novel Chromen and Benzo[h]quinoline‐Based Trisubstituted Methanes

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Discussion

Implication

Cite This Study

p‐TSA Catalyzed One‐Pot Synthesis of Novel Chromen and Benzo[h]quinoline‐Based Trisubstituted Methanes

Key Points

Discussion

Implication

Cite This Study