September 17, 2025Cancer ReportsOpen Access

Retrospective Analysis of Risk Factors and Prediction Model of Cervical Anastomotic and Intrathoracic Anastomotic Leakage After Radical Esophagectomy

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Discussion

Retrospective analysis identified key risk factors for anastomotic leakage in esophageal cancer patients, suggesting a model for early intervention.

Anastomotic leakage occurred in 95 of 776 patients, with a rate of 12.2% following esophagectomy.
Key factors linked to leakage included BMI, hypertension, chronic bronchitis, and surgical method.
A prediction model using multivariate logistic regression showed an area under the ROC curve of 0.765, indicating good predictive ability.
The findings may help clinicians improve early detection and treatment of complications after esophageal cancer surgery.

Wang et al. (2025) studied this question.

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Retrospective analysis identified key risk factors for anastomotic leakage in esophageal cancer patients, suggesting a model for early intervention.