September 17, 2025AllergyOpen Access

Predictors of Response to Biologics for Severe Asthma: A Systematic Review and Meta‐Analysis

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Response to biologics varies widely among patients with severe asthma, and identifying specific predictors improves treatment choices.
Meta-analysis of 21 studies reveals that higher blood eosinophil counts (≥ 300 cells/μL) and elevated FeNO levels (> 40 ppb) correlate with better biologic response.
This systematic review involved screening 5853 records, assessing risk of bias, and synthesizing data using the modified GRADE framework.
The findings underline the need for predictive markers beyond traditional variables, especially in populations currently underrepresented in research.

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Implication

Systematic review identifies predictors of response to biologics in severe asthma, suggesting blood eosinophil counts and FeNO levels are key indicators.

Cite This Study

Rattu et al. (2025) studied this question.

synapsesocial.com/papers/68d42c58713b0b5dfea6fce2 https://doi.org/10.1111/all.70031

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Implication

Systematic review identifies predictors of response to biologics in severe asthma, suggesting blood eosinophil counts and FeNO levels are key indicators.

Predictors of Response to Biologics for Severe Asthma: A Systematic Review and Meta‐Analysis

Key Points

Discussion

Implication

Cite This Study

Predictors of Response to Biologics for Severe Asthma: A Systematic Review and Meta‐Analysis

Key Points

Discussion

Implication

Cite This Study

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