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September 17, 2025JAMA Network OpenOpen Access

PREVENT and PCE Models for Estimating ASCVD Risk Stratified by Statin Exposure

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Authors

MLMing‐Sum LeeJOJames OnwuzurikeYWYi‐Lin Wu

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Overview

Retrospective cohort study assesses ASCVD risk estimates from PREVENT and PCE models, indicating differences based on statin exposure.

Key Points

  • PREVENT underestimated ASCVD risk in patients not treated with statins, while PCE estimates were more accurate.
  • Among 193,885 adults, 6,528 experienced an ASCVD event during follow-up.
  • Statistical comparison showed C statistics of 0.725 for PCE and 0.723 for PREVENT, indicating performance differences.
  • Observed risk differed between models, suggesting the need for updated risk assessment strategies for statin users.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68d42c51713b0b5dfea6fa3bhttps://doi.org/10.1001/jamanetworkopen.2025.32164
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