Double-blind trial reveals alterations in functional connectivity after ketamine infusion in major depression, suggesting links to receptor density.
Motivation: The exact mechanism of action of the rapid acting acting antidepressant ketamine is unknown. Goal(s): Investigation of the functional connectivity changes after acute ketamine in relation to receptor density. Approach: In a double blind placebo controlled clinical trial an infusion of ketamine or placebo was administered during resting state fMRI at 3T and functional connectivity was compared to receptor density maps. Results: The functional connectivity changes found correlate well with several receptors known to be involved with depression. Impact: This approach could be used to evaluate the effects of novel therapeutics in the brain.
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Evans et al. (2025) studied this question.
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