September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

The neurophysiological underpinnings of brain resilience: a BOLD fMRI deep phenotyping study

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Greater response variability correlates with aging and cognitive impairment, indicating brain resilience factors.
The study identifies response variability associated with neuronal activity across a whole brain level, shedding light on plasticity.
Through deep imaging protocols, the transgenic F344AD rat model provides insights into Alzheimer's disease pathology.
Developing a non-invasive MRI assay may enhance understanding of cognitive decline susceptibility and resilience.

Authors

EPEmma PineauSunnybrook Health Science Centre DADustin Loren AlmanzaSunnybrook Health Science Centre MKMargaret M. KoletarSunnybrook Health Science Centre

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Implication

Deep phenotyping reveals correlation between response variability and cognitive decline in adults, suggesting potential biomarkers for Alzheimer's disease.

Cite This Study

Pineau et al. (2025) studied this question.

synapsesocial.com/papers/68d42934713b0b5dfea6eba4 https://doi.org/10.58530/2025/4225

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Implication

Deep phenotyping reveals correlation between response variability and cognitive decline in adults, suggesting potential biomarkers for Alzheimer's disease.

The neurophysiological underpinnings of brain resilience: a BOLD fMRI deep phenotyping study

Key Points

Discussion

Implication

Cite This Study

The neurophysiological underpinnings of brain resilience: a BOLD fMRI deep phenotyping study

Key Points

Discussion

Implication

Cite This Study