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September 17, 2025Computers in Biology and MedicineOpen Access

Subtle changes in clonal dynamics: Challenges in quantifying the slow expansion of small hematopoietic stem cell clones

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Authors

SWSebastian WagnerLTLars ThieleckeIGIngmar Glauche

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Overview

Mathematical modeling reveals challenges and implications of clonal competition in hematopoietic stem cells, highlighting measurement issues.

Key Points

  • Small hematopoietic stem cell clones show slow expansion over decades, complicating disease tracking.
  • Our stochastic model indicates that low-abundance clones can appear stable despite ongoing competition, with potential implications for disease.
  • Increased proliferative activity linked to inflammation may accelerate pre-malignant clonal growth, influencing dynamics.
  • Short-term data may misrepresent clonal behavior due to measurement uncertainty, requiring longer follow-up for accurate assessment.

Cite This Study

Wagner et al. (2025) studied this question.

synapsesocial.com/papers/68d42725713b0b5dfea6dc1ahttps://doi.org/10.1016/j.compbiomed.2025.111079
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