Bilayer oxidized sodium alginate-carboxymethyl chitosan hydrogel microspheres enable sustained BMP-2 release for enhanced bone regeneration

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Sustained release of BMP-2 from the developed microspheres promotes enhanced bone regeneration.
In vitro experiments showed significant osteogenic effects on rat bone marrow mesenchymal stem cells with sustained BMP-2 delivery.
The bilayer structure of hydrogel microspheres effectively delays BMP-2 release, facilitating controlled dosing for bone healing.
In vivo implantation of the microspheres alongside calcium phosphate cement indicates promising clinical applications for bone defect repair.

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Hydrogel microspheres enable sustained BMP-2 release, improving osteogenic efficacy in rat models.

Yuan et al. (2025) studied this question.

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