September 16, 2025

Diagnostic and Prognostic Value of Myocardial Flow Reserve Quantification with Single Photon Emission Computed Tomography – a Systematic Review and Meta-Analysis

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SPECT-derived myocardial flow reserve correlates well with invasive coronary angiography standards, indicating strong diagnostic accuracy.
Pooled sensitivity of 78.5% and specificity of 89.3% found through meta-analysis of 32 studies, demonstrating reliable performance.
Quantitative myocardial flow reserve consistently predicts major adverse cardiac events, independent of coronary obstruction status.
Further standardization and validation of SPECT protocols are essential to enhance clinical implementation and accessibility.

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Systematic review assesses SPECT-derived myocardial flow reserve in coronary artery disease, suggesting its prognostic potential.

Baksa et al. (2025) studied this question.

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