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September 16, 2025Journal of Shahrekord University of Medical SciencesOpen Access

Evaluation of sub-chronic adverse effects of Dracocephalum kotschyi hydroalcoholic extract on blood biochemical and hematological biomarkers in rats

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Authors

AHAli Hosseini-SharifabadIsfahan University of Medical SciencesNRNastaran RahimirigiIsfahan University of Medical SciencesHSHassan SadraeiIsfahan University of Medical Sciences

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Implication

Experiment evaluates biochemical and hematological biomarkers in Wistar rats, indicating potential toxicity with high doses.

Key Points

  • Hydroalcoholic extract of D. kotschyi at 300 mg/kg significantly increased liver enzymes and creatinine levels.
  • ALT and alkaline phosphatase showed significant elevation at 75 mg/kg, suggesting dose-dependent effects.
  • Blood and tissue samples indicated no major adverse effects at lower doses, maintaining biomarker stability.
  • No significant changes were observed in glucose, thyroid hormones, or complete blood count despite higher extract doses.

Cite This Study

Hosseini-Sharifabad et al. (2025) studied this question.

synapsesocial.com/papers/68d42645713b0b5dfea6cbfchttps://doi.org/10.34172/jsums.961
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