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September 16, 2025Molecular PsychiatryOpen Access

Multi-epigenome-wide analyses and meta-analysis of child maltreatment in judicial autopsies and intervened children and adolescents

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Authors

SNShota NishitaniTFTakashi X. FujisawaSTShinichiro Takiguchi

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Implication

Meta-analysis identifies DNA methylation signatures in children with maltreatment, suggesting biomarkers for future interventions.

Key Points

  • Methylation risk scores differentiated individuals who experienced child maltreatment, with an AUC of 0.672.
  • Meta-analysis revealed four significant CpG sites, notably within the FOXP1 gene associated with size changes in key brain areas.
  • Methylation of FOXP1 linked to structural brain alterations involved in emotional regulation and social cognition.
  • Findings support the role of epigenetic modifications in contributing to psychopathology and childhood adversity.

Cite This Study

Nishitani et al. (2025) studied this question.

synapsesocial.com/papers/68d4263f713b0b5dfea6ca2ehttps://doi.org/10.1038/s41380-025-03236-1
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