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September 16, 2025International Journal of Biological SciencesOpen Access

PGK1 Regulates Oxidative Stress in Gestational Diabetes Mellitus through the Estradiol-Keap1-Nrf2 Pathway

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Authors

YPYou PengHZHengli ZhaoJCJun Chen

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Overview

Pharmacological inhibition of PGK1 reduces oxidative stress in gestational diabetes models, suggesting potential therapeutic targets.

Key Points

  • Inhibition of PGK1 reduced oxidative stress, improving pregnancy outcomes in gestational diabetes models.
  • Pharmacological PGK1 inhibition decreased ROS production and enhanced antioxidant protein expression, notably Nrf2.
  • The study illustrates the estradiol-Keap1-Nrf2 pathway's role in regulating oxidative stress through PGK1.
  • These findings highlight PGK1 as a potential therapeutic target for oxidative stress-related pregnancy complications.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68d4262e713b0b5dfea6bf69https://doi.org/10.7150/ijbs.113728
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