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September 16, 2025BiologyOpen Access

The Role of AI-Driven De Novo Protein Design in the Exploration of the Protein Functional Universe

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Authors

GZGuohao ZhangCLChuanyang LiuJLJiajie Lu

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Overview

Review highlights AI's role in overcoming traditional protein engineering limits and enhancing biotechnology.

Key Points

  • AI-driven protein design accelerates exploration of the protein functional universe, paving new pathways in biotechnology.
  • Key applications in therapeutic, catalytic, and synthetic biology illustrate the promise of AI in protein engineering.
  • This comprehensive review examines methodologies for designing proteins with customized folds and functions.
  • Despite advancements, challenges remain in fully harnessing AI's potential for protein functional exploration.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d4233c713b0b5dfea6bc50https://doi.org/10.3390/biology14091268
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  5. 5Generative AI techniques for conformational diversity and evolutionary adaptation of proteins2025 · 6 citations