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September 16, 2025Applied SciencesOpen Access

Diagnostic Accuracy of Presepsin, sMR, and Established Inflammatory Biomarkers in Critically Ill Children with Sepsis or Systemic Inflammatory Response Syndrome

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Authors

AHAdriana Hadzhieva-HristovaDGDaniela GerovaSSSevim Shefket

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Overview

Prospective study evaluates diagnostic ability of presepsin and sMR in pediatric sepsis, indicating improved accuracy with biomarker combinations.

Key Points

  • The combination of sMR, CRP, and PCT achieved the highest diagnostic accuracy for pediatric sepsis.
  • Serum levels of presepsin and soluble mannose receptor were significantly elevated in critically ill patients.
  • ROC curves revealed that no single biomarker could reliably distinguish sepsis from non-infectious SIRS.
  • The study involved 80 children, including 53 admitted to the PICU and 27 healthy controls.

Cite This Study

Hadzhieva-Hristova et al. (2025) studied this question.

synapsesocial.com/papers/68d42336713b0b5dfea6b96bhttps://doi.org/10.3390/app151810089
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