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September 16, 2025Open Access

Biologics for Eosinophilic Oesophagitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Authors

RKRakhshanda KhanMBManisha BokkaBJBharadwaj Jilakaraju

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Overview

Systematic review examines biologics' effects on histological remission in eosinophilic oesophagitis, suggesting safety implications.

Key Points

  • Biologics significantly increased histological remission in eosinophilic oesophagitis compared to placebo.
  • Among 1,706 participants, benralizumab and lirentelimab showed the strongest efficacy in achieving remission.
  • Existing therapies often fail to provide adequate relief, highlighting biologics as promising alternatives.
  • No overall increase in adverse events was observed, supporting the safety of biologic treatments.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68d42336713b0b5dfea6b7b4https://doi.org/10.1101/2025.09.14.25335718
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