The role of helicobacter in gastric cancer prevention

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Discussion

This review investigates the mechanisms of helicobacter in gastric cancer prevention, suggesting new therapeutic approaches.

H. pylori eradication reduces gastric cancer incidence in both healthy individuals and patients.
Significant mechanisms include activation of the NF-κB pathway and contributions from oxidative stress.
The review emphasizes the need for integrated strategies combining eradication and vaccination for effective prevention.
Future research should focus on microbiome management and innovative vaccination strategies against H. pylori.

Ghamdi et al. (2025) studied this question.

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