September 16, 2025Frontiers in OncologyOpen Access

The predictive value of PSMA PET/CT in determining pathological upgrading of prostate cancer: A pooling up analysis

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Discussion

Meta-analysis assesses PSMA PET/CT's predictive value for pathological upgrading in prostate cancer, suggesting clinical implications.

PSMA PET/CT shows moderate accuracy, predicting pathological upgrading with a sensitivity of 68% and specificity of 74%.
The analysis included 7 studies with a total of 507 patients, all diagnosed with biopsy-confirmed prostate cancer.
The pooled diagnostic accuracy yielded an area under the ROC curve of 0.74, indicating reasonable predictability.
Further investigations are essential to clarify heterogeneity and enhance the clinical application of PSMA PET/CT.

Liu et al. (2025) studied this question.

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