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September 16, 2025Frontiers in ImmunologyOpen Access

STING-targeting PROTACs: emerging therapeutic tools for enhanced immunotherapy in inflammatory diseases

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Authors

WJWenqing JiangXYXiaoping YangHLHuiying Liu

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Implication

Review evaluates STING-targeting PROTACs, highlighting enhanced immunotherapy for inflammatory diseases, and addressing risks of immune suppression.

Key Points

  • STING-targeting PROTACs may enable sustained suppression of pathological signaling, offering new therapeutic strategies.
  • Traditional therapies face limitations, while PROTACs could provide selective degradation of STING for better outcomes.
  • The review discusses challenges such as selectivity for pathological STING activity and risks associated with immune suppression.
  • Critical gaps in biomarker development and translational challenges are noted, emphasizing the need for enhanced specificity.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68d42321713b0b5dfea6ad0ehttps://doi.org/10.3389/fimmu.2025.1631132
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