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September 16, 2025Asian Journal of Pharmaceutical and Clinical ResearchOpen Access

Effect of Euphorbia Milii Extract on Cytotoxicity and Hepatoprotective Activity Against Paracetamol-Induced Hepatic Damage in Wistar Rats

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Authors

KBK. K. Raja BabuPSP. Shanmugasundaram

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Overview

Observational analysis revealed hepatoprotective activity of Euphorbia milii extract against paracetamol-induced injury, suggesting potential as a natural remedy.

Key Points

  • Euphorbia milii extract significantly reduced liver enzyme levels and maintained liver structure, showing promise for treating liver damage.
  • In vitro cytotoxicity tests indicated over 70% cell viability for Euphorbia milii extract, confirming it as non-cytotoxic and safe for biological use.
  • The extract demonstrated a dose-dependent enhancement in antioxidant activity by decreasing lipid peroxidation and increasing glutathione levels.
  • Histopathological evaluations corroborated the biochemical data by showing preserved liver architecture in extract-treated Wistar rats.

Cite This Study

Babu et al. (2025) studied this question.

synapsesocial.com/papers/68d42321713b0b5dfea6abf3https://doi.org/10.22159/ajpcr.2025v18i9.55465
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