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September 16, 2025Asian Journal of Pharmaceutical and Clinical ResearchOpen Access

Target-Oriented Molecular Docking and Admet Analysis of Novel Chalcone-Linked Quinoline Derivatives for Cancer Therapy

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Authors

TKTejinder KaurDBDeepak BhandariRSRajiv Sharma

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Overview

Molecular docking reveals effective anticancer candidates targeting EGFR, suggesting robust drug properties.

Key Points

  • Chalcone-linked quinoline derivatives exhibited potential as anticancer agents against EGFR tyrosine kinase.
  • Key protein-ligand interactions showed stable hydrogen bonds with amino acid residues in the EGFR binding pocket.
  • Computational analysis using Maestro interface and ADME predictions indicated favorable drug-like properties overall.
  • Results support further exploration of these novel derivatives in cancer therapy targeting EGFR enzyme.

Cite This Study

Kaur et al. (2025) studied this question.

synapsesocial.com/papers/68d42321713b0b5dfea6abdahttps://doi.org/10.22159/ajpcr.2025v18i9.55390
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