September 16, 2025European PsychiatryOpen Access

High-Dose Accelerated Bilateral Theta Burst Stimulation for Depression and Anxiety: The Seville Protocol

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High-dose theta burst stimulation significantly reduced depression and anxiety symptoms in treatment-resistant patients.
Among 101 participants, remission rates were 29.2% for depression and 22% for anxiety, with notable response rates.
This analysis employed mixed-effects models to assess changes in HAM-D and HAM-A scores, showing significant reductions.
Factors influencing treatment response included age and family history of mental health conditions, suggesting personalized treatment.

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Accelerated TBS improves depression and anxiety in treatment-resistant patients, indicating potential benefits of tailored approaches.

Martín-Bejarano et al. (2025) studied this question.

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