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September 16, 2025Chinese Medical JournalOpen Access

Single-cell analysis identifies PI3+S100A7+ keratinocytes in early cervical squamous cell carcinoma with HPV infection

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Authors

PFPeiwen FanDDDanning DongYFYaning Feng

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Overview

Single-cell rna sequencing reveals keratinocyte and macrophage interactions in cervical cancer, indicating prognostic implications.

Key Points

  • Higher infiltration of PI3+S100A7+ keratinocytes correlates with poor prognosis in early cervical squamous cell carcinoma.
  • Single-cell rna sequencing uncovered significant differences in keratinocyte populations between tumors and adjacent non-cancerous tissues.
  • Interactions between PI3+S100A7+ keratinocytes and macrophages promote key signaling pathways linked to tumor progression.
  • Distinct molecular differences between HPV subtypes demonstrate varying tumor-promoting mechanisms in cervical squamous cell carcinoma.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68d42056713b0b5dfea693cfhttps://doi.org/10.1097/cm9.0000000000003795
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