September 15, 2025

Curcumin Analogs Containing Pyrazole-Pyridine Hybrids as Novel Anticancer Agents: Synthesis, Cytotoxicity, Apoptosis Induction, and Molecular Modeling.

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Synthesis of novel curcumin analogs shows enhanced cytotoxicity against human cancer cells, indicating potential benefits.

Curcumin analog 4c exhibits the strongest cytotoxicity against various human cancer cell lines, including HepG2.
Compound 4c significantly induces apoptosis in HepG2 cells, demonstrating its anticancer potential and effectiveness.
Structural modifications using bioisosteric replacement enhance the anticancer activities and properties of curcumin analogs.
The binding mode of compound 4c at the colchicine-binding site indicates favorable physicochemical and pharmacokinetic properties.

Doan et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark