September 12, 2025

Testing Performance of mNGS in Febrile Patients with Hematological Disease and Its Guiding Value for Fever Management in Clinical Treatment

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Retrospective analysis shows mNGS improves pathogen identification in febrile patients, suggesting effective fever management.

mNGS test detected pathogens in 68.27% of samples, outperforming blood culture (7.69%) and routine tests (16.35%).
Pathogen identification included 60.74% viruses, outperforming CBC and routine tests for mixed infections.
Predictive modeling revealed pulmonary infection and neutropenia significantly influence mNGS test outcomes.
mNGS results led to improved survival rates (75.0%) through tailored treatments, indicating clinical value.

Song et al. (2025) studied this question.

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