September 12, 2025Open Access

Prognostic Role of Third-Day CRP, Lactate and MechanicalVentilation in Predicting ICU Mortality in Sepsis: A Single-Center Study

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Retrospective cohort study reveals third-day CRP and lactate, alongside mechanical ventilation, predict 30-day mortality in ICU sepsis patients.

Higher third-day CRP and lactate levels significantly correlate with increased 30-day mortality in sepsis patients.
Among 200 patients, 30-day mortality rate was found to be 41.5%, with significant differences in biomarker levels between survivors and non-survivors.
Multivariable analysis identified third-day CRP, lactate, and mechanical ventilation as independent predictors of mortality in this population.
The combined predictive model demonstrated excellent discrimination with an AUC of 0.919, indicating high reliability in assessing patient outcomes.

Uğuz et al. (2025) studied this question.

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Retrospective cohort study reveals third-day CRP and lactate, alongside mechanical ventilation, predict 30-day mortality in ICU sepsis patients.