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September 12, 2025BiomedicinesOpen Access

Neoantigen-Driven Immunotherapy in Triple-Negative Breast Cancer: Emerging Strategies and Clinical Potential

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Authors

PSP.A. ShatalovАБА. А. БукаеваEVEgor Veselovsky

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Overview

This review uncovers emerging immunotherapy strategies targeting neoantigens in triple-negative breast cancer, indicating its therapeutic promise.

Key Points

  • Neoantigen-driven therapies show potential to improve outcomes in patients with triple-negative breast cancer.
  • The strong presence of private neoantigens suggests personalized approaches may be more effective than shared variants.
  • The analysis of the tumor microenvironment highlights its dual role in immunoactivation and suppression affecting therapy success.
  • Challenges in neoantigen research include prediction inaccuracies and high costs, suggesting a need for combinational strategies and better delivery.

Cite This Study

Shatalov et al. (2025) studied this question.

synapsesocial.com/papers/68d41ee7713b0b5dfea6836ahttps://doi.org/10.3390/biomedicines13092213
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