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September 12, 2025Open Access

Cross-species brain circuitry from diffusion MRI tractography and mouse viral tracing

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Authors

SVSiva VenkadeshWLW S LinnYTYuhe Tian

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Overview

Integration of mouse viral tracing and diffusion MRI shows how species-specific circuits imply distinct organization.

Key Points

  • Finding revealed a common efficiency metric helpful for understanding the organization of connectomes across species.
  • Evidence showed the entorhinal-hippocampal projection remained efficient across all species studied.
  • Analysis used multi-objective path efficiency metrics to quantify influences between brain regions in various species.
  • Significance of findings lies in how different species maintain and diverge in neuronal circuit organization.

Cite This Study

Venkadesh et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed9713b0b5dfea67c5bhttps://doi.org/10.1101/2025.09.07.674762
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Also Consider

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  1. 1Directed fMRI connectivity mapping reveals a flexible functional hierarchy in the mouse brain2025
  2. 2Cross-species standardised cortico-subcortical tractography2025
  3. 3Cross-species Standardised Cortico-Subcortical Tractography2025
  4. 4Ex vivo diffusion MRI protocol optimization on the Connectome 2.0 scanner for reconstructing cortico-subcortical projections2025
  5. 5Reconstruction of a connectome of single neurons in mouse brains by cross-validating multi-scale multi-modality data2025