September 12, 2025Experimental PhysiologyOpen Access

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

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Authors

JLJie LinZhejiang Chinese Medical University LHLei HanBGI Research ZMZhigang Ma

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Implication

Exploration of ginsenoside‐MC1 and irisin therapy reduced mitochondrial apoptosis in diabetic rats, indicating significant protective effects against liver injury.

Key Points

Combined therapy with ginsenoside‐MC1 and irisin significantly reduced AST, ALT, and LDH levels in diabetic rats with liver injury.
The treatment restored mitochondrial function by upregulating Bcl‐2 while downregulating Bax and cleaved caspase‐3, improving overall liver health.
Through AMPK/JNK signalling pathways, mitochondrial apoptosis was suppressed, showcasing its potential as a therapeutic approach for diabetic complications.
These findings highlight the significance of mitochondria-targeted therapy for improving outcomes in diabetes-induced hepatic injury.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed2713b0b5dfea67a62 https://doi.org/10.1113/ep092982

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Implication

Exploration of ginsenoside‐MC1 and irisin therapy reduced mitochondrial apoptosis in diabetic rats, indicating significant protective effects against liver injury.

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

Discussion

Member takes

Implication

Key Points

Cite This Study

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