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September 12, 2025ACS OmegaOpen Access

Pluronic F-68 Triblock Copolymer Architecture for a Next-Generation Self-Nanoemulsifying System: Overcoming Drug Trapping and Dosage Challenges of Candesartan Cilexetil

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Authors

ASAbdelrahman Y. SherifMIMohamed Abbas Ibrahim

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Overview

Analysis reveals a new IL-SNEDDS formulation enhances dissolution of candesartan cilexetil, suggesting improved dosage efficiency.

Key Points

  • IL-SNEDDS formulation improved the dissolution of candesartan cilexetil compared to S-SNEDDS, overcoming drug trapping.
  • The optimum L-SNEDDS formulation significantly enhances drug solubility with no adverse chemical interactions noted.
  • Physicochemical characterization confirmed the amorphous state of candesartan cilexetil in the studied formulations.
  • The incorporation of Pluronic F-68 helps create a liquefying system that could solve dosage challenges for self-nanoemulsifying systems.

Cite This Study

Sherif et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed2713b0b5dfea679a5https://doi.org/10.1021/acsomega.5c06315
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