September 12, 2025Seminars in Arthritis and RheumatismOpen Access

The prognostic importance of worsening dyspnoea in systemic sclerosis related interstitial lung disease

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Authors

KMKathleen MorrisroeThe University of Melbourne DHDylan HansenSt. Vincent's Birmingham WSWendy StevensSt Vincent's Hospital

Discussion

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Implication

Observational analysis reveals worsening dyspnoea predicts mortality in systemic sclerosis-related interstitial lung disease, highlighting its clinical value.

Key Points

Worsening dyspnoea is strongly linked to higher mortality in patients with systemic sclerosis-related ILD.
In a cohort of 2198 SSc patients, 38.3% developed progressive ILD over approximately 5.8 years of follow-up.
Patient-reported worsening dyspnoea was associated with mortality similar to established definitions of progressive ILD.
Accelerated failure time analysis confirmed that dyspnoea offers critical prognostic information for SSc-ILD outcomes.

Cite This Study

Morrisroe et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed2713b0b5dfea678f3 https://doi.org/10.1016/j.semarthrit.2025.152826

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Implication

Observational analysis reveals worsening dyspnoea predicts mortality in systemic sclerosis-related interstitial lung disease, highlighting its clinical value.