September 12, 2025Epidemiology Biostatistics and Public HealthOpen Access

Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin

View Full Paper

Ask AI

Bookmark

Authors

LFLuisa Foco MBMarzia De BortoliEurac Research FMFabiola Del Greco M

Discussion

Member takes

Implication

This research demonstrates how two-sample mendelian randomization can reveal drug targets in familial arrhythmogenic cardiomyopathy, suggesting a role for long non-coding RNA.

Key Points

Downregulating DSP-AS1 resulted in increased levels of DSP protein, indicating a potential drug target.
The QRS interval showed significant association with genetic variants near DSP and DSP-AS1, highlighting causal relations.
Analyses included data from 4342 participants, assessed using linear mixed models for electrocardiographic traits.
Experimental validation using hiPSC-CMs resolved uncertainties related to statistical replication in two-sample mendelian randomization.

Cite This Study

Foco et al. (2025) studied this question.

synapsesocial.com/papers/68d41eca713b0b5dfea6768c https://doi.org/10.54103/2282-0930/29455

View Full Paper

Ask AI

Bookmark

Implication

This research demonstrates how two-sample mendelian randomization can reveal drug targets in familial arrhythmogenic cardiomyopathy, suggesting a role for long non-coding RNA.

Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin

Discussion

Member takes

Implication

Key Points

Cite This Study

Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider