Retrospective cohort study analyzes sacubitril/valsartan discontinuation rates in heart failure, suggesting age and antidepressants influence treatment adherence.
Key Points
The discontinuation proportion of sacubitril/valsartan was found to be 20%, indicating a significant dropout rate.
Older patients showed a reduced risk of discontinuation (RR 0.987), while antidepressant use increased the risk (RR 1.430).
The cohort consisted of 1985 heart failure patients with a mean age of 65, and various treatment patterns observed.
Monitoring healthcare data continuously is essential for evaluating the effectiveness and compliance with sacubitril/valsartan over time.