September 12, 2025Journal of Cellular and Molecular MedicineOpen Access

Ferroptosis in Haematological Malignancies: From Regulatory Networks to Novel Therapeutic Opportunities

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Authors

MSMaryam ShayanmaneshIran University of Medical Sciences SASeyed Esmaeil AhmadiUniversity of Zurich AAAli AminiIran University of Medical Sciences

Discussion

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Implication

This review discusses ferroptosis mechanisms and potential therapeutic opportunities in haematological malignancies, emphasizing ferroptosis inducers.

Key Points

Ferroptosis may provide effective treatment strategies for haematological malignancies, reducing drug resistance.
Ferroptosis inducers target pathways like glutathione production and lipid metabolism, showing promise in therapy.
Research highlights the role of ferroptosis-related genes and non-coding RNAs in regulating ferroptosis mechanisms.
Exploration of novel therapies based on ferroptosis can transform treatment approaches for blood cell disorders.

Cite This Study

Shayanmanesh et al. (2025) studied this question.

synapsesocial.com/papers/68d41dae713b0b5dfea67341 https://doi.org/10.1111/jcmm.70790

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Implication

This review discusses ferroptosis mechanisms and potential therapeutic opportunities in haematological malignancies, emphasizing ferroptosis inducers.