September 12, 2025VaccinesOpen Access

Identification of T-Cell Epitopes and Vaccine Development for African Swine Fever Virus

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African swine fever virus has caused severe impacts on the global pig industry, highlighting vaccine needs.
Research is limited, with fewer than 20 ASFV proteins having identified T-cell epitopes, indicating a major research gap.
Challenges such as swine leukocyte antigen polymorphism complicate the efficacy of T-cell epitope predictions.
Continuous advancements in T-cell immunology are essential for overcoming barriers in vaccine development for ASFV.

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This review highlights challenges in T-cell epitope identification in ASFV, suggesting improvements in vaccine development strategies.

Ni et al. (2025) studied this question.

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