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September 12, 2025Journal of Pharmacy & Pharmacognosy Research

Randomized controlled trial on the regulation of MMP-9-NGAL ratio in diabetic patients with early renal dysfunction by Piper crocatum Ruiz & Pav. functional foods

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Authors

ASAndina SetyawatiHasanuddin UniversityNJNuurhidayat JafarHasanuddin UniversityMRMuhammad RaihanHasanuddin University

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Implication

Randomized trial reduced MMP-9 and NGAL in diabetic patients, indicating potential for functional foods.

Key Points

  • P. crocatum supplementation led to significant reductions in MMP-9 and NGAL in diabetic patients with renal dysfunction.
  • MMP-9 levels decreased from 518.45 to 350.34 ng/mL, while NGAL levels dropped from 195.67 to 174.31 ng/mL.
  • The double-blind, randomized, placebo-controlled trial included 387 participants consuming P. crocatum-enriched cookies.
  • Findings suggest P. crocatum may serve as a complementary therapy for diabetic nephropathy.

Cite This Study

Setyawati et al. (2025) studied this question.

synapsesocial.com/papers/68d41da1713b0b5dfea66a42https://doi.org/10.56499/jppres25.2499_13.6.1847
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Empowering Diabetes Management through Nutritional Innovations: The Role of Golden Rice Cookies Enriched with Piper crocatum Extract2025
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  5. 5Targeting α-Klotho Protein by Agmatine and Pioglitazone Is a New Avenue against Diabetic Nephropathy2025 · 2 citations