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September 12, 2025Open Access

Autoantibodies targeting CRB2 and Nephrin correlate with extrafollicular B cells in idiopathic podocytopathies

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Authors

TATho-Alfakar Al-AubodahSLSimon LeclercLALamine Aoudjit

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Overview

Analysis shows anti-CRB2 autoantibody prevalence and B cell dysregulation in podocytopathies, indicating important immune mechanisms.

Key Points

  • Anti-CRB2 autoantibody is prevalent across disease phenotypes and accumulates preferentially in adults.
  • Both anti-CRB2 and anti-nephrin correlate with the expansion of T-bet+ CD21low atypical B cells in children.
  • Elevated classical memory B cells in adults indicate greater B cell dysregulation compared to children.
  • Dysregulated B cell pools in children show activation potential and preferential VH4-39+ B cell clonotypes.

Cite This Study

Al-Aubodah et al. (2025) studied this question.

synapsesocial.com/papers/68d41d94713b0b5dfea66557https://doi.org/10.1101/2025.09.06.674608
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