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September 12, 2025CephalalgiaOpen Access

PACAP versus CGRP in migraine: From mouse models to clinical translation

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Authors

APAdriana Della PietraAKAdisa KuburasARAndrew F. Russo

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Overview

Review examines PACAP and CGRP roles in migraine pathophysiology, suggesting new therapeutic targets.

Key Points

  • Both PACAP and CGRP elevate cAMP levels but engage distinct signaling pathways in migraine.
  • PACAP shows more effectiveness in activating alternative cAMP pathways compared to CGRP in mouse models.
  • Migraine-like behaviors induced by PACAP and CGRP occur via largely independent mechanisms.
  • Combining targeting of PACAP and CGRP could potentially enhance migraine treatment efficacy.

Cite This Study

Pietra et al. (2025) studied this question.

synapsesocial.com/papers/68d41d94713b0b5dfea6621dhttps://doi.org/10.1177/03331024251364242
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