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September 12, 2025Circulation Genomic and Precision Medicine

Age-Dependent Contributions of Rare and Common Genetic Variation in Atrial Fibrillation

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Authors

ZCZhanlin ChenPAPeter F. AzizCleveland ClinicPGPhilip GreenlandNorthwestern University

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Overview

Cross-sectional analysis identifies genetic contributions to atrial fibrillation in different age groups, suggesting varying impacts of monogenic and polygenic factors.

Key Points

  • Monogenic variants are linked to atrial fibrillation across all ages, notably stronger in those under 45.
  • Polygene risk scores show significant association with atrial fibrillation in older age groups, highlighting age-dependent effects.
  • Clinical factors considerably predict atrial fibrillation, enhanced marginally by incorporating genetic data.
  • The study reveals monogenic variants correlate with an earlier onset of atrial fibrillation, unlike polygenic risk scores.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d41c15713b0b5dfea65f44https://doi.org/10.1161/circgen.124.004958
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation2025
  2. 2Genetic evaluation of early-onset atrial fibrillation: impact on patient management2025
  3. 3A Review of Cardiomyopathy Gene Variants as Drivers of Early-Onset Atrial Fibrillation: Linking Genotype to Phenotype in Precision Medicine2026
  4. 4A Review of Cardiomyopathy Gene Variants as Drivers of Early-Onset Atrial Fibrillation: Linking Genotype to Phenotype in Precision Medicine2026
  5. 5Early onset atrial fibrillation as a marker of inherited cardiomyopathy: lessons from combined imaging and genetic assessment2026