September 12, 2025Frontiers in PharmacologyOpen Access

GLP-1 receptor agonists: exploration of transformation from metabolic regulation to multi-organ therapy

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Discussion

Review synthesizes evidence on GLP-1 receptor agonists’ pleiotropic effects, indicating potential in systemic disease treatment.

GLP-1 receptor agonists provide protection across multiple organ systems, particularly cardiovascular and renal functions.
Clinical trials show significant findings, including potential benefits in conditions like liver disease and neurodegenerative disorders.
The review highlights mechanistic expansions of GLP-1RAs from metabolic regulators to agents modulating inflammation.
These findings support future therapeutic repurposing across various diseases, although many uses remain investigational.

Gong et al. (2025) studied this question.

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